GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs7727544 | 1 | rs10076701 | chr5:131596419 | PDLIM4 | chr5:131593351-131609145:+ | -0.16 | -5.57 | 3.31E-8 | Blood metabolite levels |
| BRCA | cis | rs7727544 | 1 | rs10076701 | chr5:131596419 | SLC22A5 | chr5:131705401-131731302:+ | -0.13 | -4.84 | 1.5E-6 | Blood metabolite levels |
| BRCA | cis | rs6452524 | 1 | rs10077862 | chr5:82437141 | XRCC4 | chr5:82373317-82649577:+ | -0.12 | -3.45 | 0.000584 | Hypertension |
| BRCA | cis | rs10043228 | 1 | rs10079394 | chr5:115600919 | COMMD10 | chr5:115420727-115628978:+ | 0.23 | 4.82 | 1.66E-6 | Asthma or chronic obstructive pulmonary disease |
| BRCA | cis | rs10160456 | 1 | rs10082611 | chr11:27320108 | LGR4 | chr11:27387510-27494334:- | 0.15 | 4.4 | 1.22E-5 | Bone mineral density (paediatric, skull) |
| BRCA | cis | rs10160456 | 1 | rs10082678 | chr11:27320448 | LGR4 | chr11:27387510-27494334:- | -0.16 | -4.47 | 8.81E-6 | Bone mineral density (paediatric, skull) |
| BRCA | cis | rs10160456 | 1 | rs10082679 | chr11:27320658 | LGR4 | chr11:27387510-27494334:- | 0.15 | 4.27 | 2.16E-5 | Bone mineral density (paediatric, skull) |
| BRCA | cis | rs12435908 | 1 | rs10083488 | chr14:65853346 | LOC645431 | chr14:65877313-65879335:- | -0.23 | -4.82 | 1.64E-6 | Ischemic stroke |
| BRCA | cis | rs7647973 | 1 | rs1009051 | chr3:49521549 | AMT | chr3:49454212-49460012:- | 0.14 | 4.76 | 2.18E-6 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs1009051 | chr3:49521549 | CCDC36 | chr3:49235861-49295537:+ | 0.1 | 3.94 | 8.84E-5 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs1009051 | chr3:49521549 | GMPPB | chr3:49758932-49761384:- | -0.12 | -3.58 | 0.000353 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs1009051 | chr3:49521549 | NCKIPSD | chr3:48711280-48723334:- | 0.16 | 4.01 | 6.48E-5 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs1009051 | chr3:49521549 | P4HTM | chr3:49027341-49044579:+ | 0.09 | 3.78 | 0.000168 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs1009051 | chr3:49521549 | WDR6 | chr3:49044637-49053386:+ | -0.15 | -4.61 | 4.6E-6 | Menarche (age at onset) |
| BRCA | cis | rs1009170 | 1 | rs1009170 | chr14:92636713 | NDUFB1 | chr14:92582470-92588153:- | 0.12 | 4.06 | 5.32E-5 | Dialysis-related mortality |